Genetic Kidney Cancer Syndromes

Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation

Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic kidney cancer. In the late 1980s, the comprehensive study for hereditary kidney cancer syndrome was launched in t...

Paraneoplastic syndromes and the kidney.

A paraneoplastic syndrome is defined as a group of symptoms that develop when substances released by some cancer cells disrupt the normal function of the surrounding cells and tissue. Paraneoplastic renal syndromes are diseases that indirectly compromise tubular and glomerular function by electrolyte imbalance, hormone-producing tumors or deposition of antigen-antibody complexes in the glomerul...

Sarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review.

UNLABELLED : Sarcomas are rare mesenchymal malignancies that demonstrate great clinical and biological heterogeneity. A variety of sarcomas develop in the context of well-defined heritable cancer predisposition syndromes, associations that are often overlooked, given the rarity and diversity of sarcomas and the equivalent relative infrequency of cancer genetic syndromes. This review describes i...

special attention to genetic counseling regarding familial cancer syndromes during pregnancy (letter to editor)

introduction: performing research on (human) volunteers may involve useful or harmful effects. to preserve the volunteers' dignity, numerous world associations have issued declarations such as nuremberg's, helsinki's, belmont's report, etc. one of the four ethical principles in research is respecting volunteers' rights and the most obvious aspect of this respect materializes in obtaining the vo...

Autism and Genetic Syndromes